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Category Archive for 'Mismatch'

An assumption fundamental to medical genetics is that the DNA sequence of an allele at a particular locus will (in the vast majority of instances) be faithfully transcribed into RNA and translated into protein.  This assumption has been largely accepted in spite of known rates of transcriptional and translational errors as well as special cases […]

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In an 1858 humorous poem The Deacon’s Masterpiece, or the Wondeful One Hoss Shay, Oliver Wendell Holmes Sr. described a carriage so artfully constructed as to have no weakest link. The carriage ran smoothly for exactly a hundred years, and then one day it went to pieces all at once, – All at once, and […]

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What are the consequences of the disappearing human microbiota? by Martin J. Blaser and Stanley Falkow in Nature Reviews Microbiology   doi:10.1038/nrmicro2245 Who are we? From prions and organelles up through neighborhoods and nation-states, we are groups of groups of groups. In this thoughtful, provocative paper Blaser and Falkow remind us that 90% of our cells […]

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Early Development and Reproductive Health in Later Life One of five workshops in a conference on Evolution and Diseases of Modern Environments Organized by Randolph Nesse, at the Berlin Charité,  October 13-14, 2009 In conjunction with The World Health Summit Sponsored by the Volkswagen Foundation Session leaders: Gillian Bentley and Grazyna Jasienska In session: Gillian […]

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Summary Notes: Diet and Nutrition Workshop Workshop Rapporteurs: Jay T Stock (U Cambridge) Claudia R Valeggia (U Pennsylvania) Workshop Leader: William R Leonard (Northwestern) One of five workshops in a conference on “Evolution and Diseases of Modern Environments” Organized by Randolph Nesse, at the Berlin Charité October 13-14, 2009 In conjunction with The World Health […]

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A recent article by Hood and Jenkins provides an overview of a May 2007 Meeting on Evolutionary Medicine organized by Diddahally Govindaraju, Peter Byers and Stephen Stearns and hosted by the National Evolutionary Synthesis Center.  

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Over the past 150,000 years humans have manifestly been migratory, travelling into vastly different climatic regions of the globe. Darwinian evolution can lead to genetic differences in populations living in different climates, but any mechanism that can protect individuals from relatively short-term changes in living conditions that differ from those in which previous generations lived […]

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