http://evmedreview.com ... bridging the gap Thu, 02 Sep 2010 18:06:34 +0000 http://wordpress.org/?v=2.9.1 hourly 1 http://evmedreview.com/?page_id=69&cpage=1#comment-361 Andrew J. Luk, MD, MPH Fri, 19 Sep 2008 22:13:45 +0000 http://evmedreview.com/?page_id=69#comment-361 I am interested in the major histocompatibility complex gene HLA-B27 and why it is associated with the autoimmune disease ankylosing spondylitis and related disorders. The geographic distribution of HLA-B27 in human populations is very strongly skewed towards the higher latitudes, and it is particularly prevalent amongst indigenous peoples living on both sides of the Bering Strait, and I suspect that the gene underwent strong selective pressure as humans migrated out of Africa and into the New World. I am looking for collaborators with more experience in genetic epidemiology and evolutionary biology than I do in order to attempt to explain this striking biogeographical puzzle. I am interested in the major histocompatibility complex gene HLA-B27 and why it is associated with the autoimmune disease ankylosing spondylitis and related disorders. The geographic distribution of HLA-B27 in human populations is very strongly skewed towards the higher latitudes, and it is particularly prevalent amongst indigenous peoples living on both sides of the Bering Strait, and I suspect that the gene underwent strong selective pressure as humans migrated out of Africa and into the New World. I am looking for collaborators with more experience in genetic epidemiology and evolutionary biology than I do in order to attempt to explain this striking biogeographical puzzle.

]]>