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Tag Archive 'virus neutralization'

Evolutionary Origins of a Potent Broadly-Neutralizing Antibody to HIV-1

Posted in Defenses, Genetics, Immunology, Infection, evolutionary medicine on Jul 24th, 2010

Two recent papers published online at scienceexpress.org describe studies of antibodies claimed to interfere with infection of host cells by a wide range of HIV-1 strains.  These studies strongly suggest that the evolutionary potential of the humoral immune response may be necessary to combat the diversity of HIV-1 antigens that results from the extraordinary pace [...]

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Selection and the Context-Dependence of Phenotypic Optimization

Posted in Immunology, Infection, Trade-offs, evolutionary medicine on Nov 28th, 2009

I recently saw the movie, “The Blind Side,” based on a book of almost the same name (“The Blind Side: Evolution of a Game”) by author, Michael Lewis. The reference to “evolution” in the book title refers to the adaptations necessitated in the (American) game of football on the offensive line, especially at the left tackle [...]

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Thanks to Jeff Kopmanis at the University of Michigan for technical help that makes this publication possible.