The emerging medical ecology of the human gut microbiome

By John W. Pepper and Simon Rosenfeld
in Trends in Ecology and Evolution   http://dx.doi.org/10.1016/j.tree.2012.03.002  (not open access)

Abstract: It is increasingly clear that the human gut microbiome has great medical importance, and researchers are beginning to investigate its basic biology and to appreciate the challenges that it presents to medical science. Several striking new empirical results in this area are perplexing within the standard conceptual framework of biomedicine, and this highlights the need for new perspectives from ecology and from dynamical systems theory. Here, we discuss recent results concerning sources of individual variation, temporal variation within individuals, long-term changes after transient perturbations and individualized responses to perturbation within the human gut microbiome.