Forty years on from Nixon’s war, cancer research ‘evolves’

by Nadia Drake  in   Nature Medicine      doi:10.1038/nm0711-757  (Not open access)       Published online   07 July 2011

Up a tree: Cancer researchers look to Darwin to improve tumor therapies.

SAN FRANCISCO — Ever since US president Richard Nixon declared war on cancer in 1971, scientists and physicians have launched  a full-on offensive against the disease, seeking  to cure cancer by eradicating the multiplying  enemy cells. But, with few exceptions, treatments haven’t lived up to expectations. “We’ve been banging our heads against this cure thing for three, four decades now and really made almost zero progress,” says Carlo Maley, a cancer researcher at the University of California–San Francisco (UCSF). “It’s been a wash.”
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Now, Maley and others suggest that applying the principles of evolutionary biology to cancer research could do what that the existing paradigm has missed—and the idea is gaining traction. At the first biannual international  Evolution and Cancer Conference, held here  during the first weekend in June, around 125  scientists met to discuss how considering fields  not typically associated with cancer—including  evolutionary dynamics, comparative biology  and even social psychology—might help turn  the tide in the fight against the deadly disease…


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