Continuous In Vitro Directed Evolution of Macromolecules

Evolutionary processes, and specifically selection-based mechanisms, have long served to inspire in vitro methods for generating proteins and nucleic acids that mediate functions of interest.  Examples going back two decades include the development of phage...

Evolutionary Erosion of Anti-Microbial Magic

In the early years of the last century, Paul Ehrlich coined the term “magic bullet” to indicate a therapeutic agent that targeted an infectious agent or tumor with exquisite specificity (Schwartz, 2004).  He was inspired by his work with antibodies to imagine a future...