Randy Nesse recently reviewed a new book (“The Evolution of Obesity” by Power and Schulkin) on weight regulation [Nature, 2009)]. In the course of the review, Nesse took note of the authors’ evidence that leptin-associated function is highly...
Geneticists and evolutionary biologists have for decades embraced the view, no doubt reinforced by terminology such as “silent” (i.e., synonymous) mutations, that for protein-encoding genes, genotype determines phenotype through control of the amino acid...