Trends in Ecology & Evolution, Volume 26, Issue 4, 175-182, 07 February 2011
10.1016/j.tree.2011.01.002
Authors Aleah F. Caulin, Carlo C. Maley
Summary
The evolution of multicellularity required the suppression of cancer. If every cell has some chance of becoming cancerous, large, long-lived organisms should have an increased risk of developing cancer compared with small, short-lived organisms. The lack of correlation between body size and cancer risk is known as Peto’s paradox. Animals with 1000 times more cells than humans do not exhibit an increased cancer risk, suggesting that natural mechanisms can suppress cancer 1000 times more effectively than is done in human cells. Because cancer has proven difficult to cure, attention has turned to cancer prevention. In this review, similar to pharmaceutical companies mining natural products, we seek to understand how evolution has suppressed cancer to develop ultimately improved cancer prevention in humans. buy prelone online https://infoblobuy.com/prelone.html no prescription
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This is simply another example of an adaption that is geared to producing and raising the next generation. In humans and other long lived mammals. Intracellular programmes detect DNA damage and delay normal activities and cell division whilst repairs are carried out. In humans, with extended childhood, aprogramme of repair is selected for that allows adults to reproduce and survive until our offspring are independant “hunter gatherers” with minimal risk of our lives being cut short by an aggressive cancer.