Arguably, the most exciting trend of the last decade in chemotherapy for tumors based on traditional small molecule agents is the use of drugs that target specific protein kinases that participate in signaling pathways crucial for tumor growth (Solit and Sawyers,...
In the early years of the last century, Paul Ehrlich coined the term “magic bullet” to indicate a therapeutic agent that targeted an infectious agent or tumor with exquisite specificity (Schwartz, 2004). He was inspired by his work with antibodies to imagine a future...
I recently had the opportunity to learn first-hand about the research of Robert Gatenby. Dr. Gatenby is a radiologist, but he is probably not your typical radiologist. He has been employing mathematical methods and the principles and concepts of evolutionary biology...
In the April 16, 2010, issue of Cell Jon McClellan and Mary-Claire King published a commentary that addressed the nature of the genetic variation that accounts for common human diseases, an issue of profound importance in evolutionary medicine. The authors also...
Since the announcement, approximately ten years ago in June of 2000, that a first draft of the (almost) complete nucleotide sequence of a human genome had been assembled, much interest has been directed to the ways in which genomic information can facilitate...
