In previous commentaries (http://dev-evmedreview.pantheonsite.io/?p=1863; http://dev-evmedreview.pantheonsite.io/?p=837; http://dev-evmedreview.pantheonsite.io/?p=385), I have discussed the critical role of extensive B-cell and immunoglobulin gene evolution in...
It would be hard to identify an approach to cancer treatment that has received more attention recently than anti-checkpoint therapy (Pollack, 2015). This strategy for eliminating tumor cells is based on interfering with one or another pathway that inhibits the...
In an EMR commentary (http://evomed.org/?p=1644) from March two years ago, I discussed issues related to the functional classification of genomic DNA sequences that arose in the context of claims from the ENCODE (ENCyclopedia Of DNA Elements) consortium. A particular...
Last month, Murphy and colleagues (Cell, 2015) published a fascinating report about a patient with an immunodeficiency syndrome that underwent spontaneous resolution. The mechanism for this remarkable outcome points to the importance of somatic cell selection and...
Carcinomas of the prostate are the most common cancers affecting men and a leading cause of male cancer deaths in the United States (CDC web site, Cancer Prevention and Control). Given the unique association of the prostate with males, it makes sense that prosate...
