Cancer stem cells as ‘units of selection’

By Mel Greaves, in Evol Appl. 2013 Jan;6(1):102-8. doi: 10.1111/eva.12017. Open access Cancer development is widely recognized to be a somatic cell evolutionary process with complex dynamics and highly variable time frames. Variant cells and descendent subclones gain...

Have TB strains co-evolved with human subpopulations?

HIV Infection Disrupts the Sympatric Host–Pathogen Relationship in Human Tuberculosis    By  Fenner L, Egger M, Bodmer T, Furrer H, Ballif M, et al. (2013) . PLoS Genet 9(3): e1003318. doi:10.1371/journal.pgen.1003318   Open Access Author Summary  Human tuberculosis...

Preeclampsia and Parent-Offspring Conflict

Parent-Offspring Conflict and the Persistence of Pregnancy-Induced Hypertension in Modern Humans By  Hollegaard B, Byars SG, Lykke J, Boomsma JJ (2013) .PLoS ONE 8(2): e56821. doi:10.1371/journal.pone.0056821  Open access Abstract: Preeclampsia is a major cause of...

An Evolutionary Perspective on Epistasis and the Missing Heritability

By Hemani G, Knott S, Haley C (2013) . PLoS Genet 9(2): e1003295.doi:10.1371/journal.pgen.1003295  (open access) The relative importance between additive and non-additive genetic variance has been widely argued in quantitative genetics. By approaching this question...