Evolutionary Foundations for Medicine and Public Health: Focus on Infection and Cancer
August 6-10 at the Mount Desert Island Biological Laboratory, Bar Harbor, Maine
Registration now open.
CME credit available
This course will be limited to 40 participants. It will be appropriate for those with a background in biology and/or medicine at diverse levels. Special expertise in evolutionary biology is not required, however those who have already studied evolutionary biology will have specialized opportunities. In order to maximize benefits to this developing field, admission preference will be offered to physicians and professors who teach or anticipate teaching courses on the subject, and to members of minority groups who may be eligible for support from the National Evolutionary Synthesis Center. Researchers and students from advanced undergraduate to postdocs will be warmly welcomed.
Faculty
Randolph Nesse – University of Michigan (Course director)
Douglas Brash — Yale University
Carlo Maley – University of California San Francisco
Athena Aktipis — University of California San Francisco and Arizona State University
Andrew Read – Pennsylvania State University
Mark Schwartz—New York University
Stephen Stearns – Yale University
Robert Woods — University of Michigan
Description
This intensive one-week course will introduce strategies for applying core principles of evolutionary biology to problems in medicine and public health, with a special focus on infection and cancer. The course will not attempt to cover all possible applications, it will focus on a few examples. Some especially relevant principles include life history theory, host pathogen co-evolution, the regulation of defenses, developmental plasticity, and trade-offs shaping reproductive strategies. These principles will be applied to clinically relevant topics including aging, antibiotic resistance, clinical management of fever, endothelial disease, prenatal experience and metabolic syndrome, and reproductive cancers. This year’s course will have extensive special expertise available on topics related to cancer and infectious disease. Mornings will be devoted to lectures and structured discussions. After lunch, participants will gather in small groups for faculty led discussions on a number of specialized topics such as strategies to prevent antibiotic resistance, the role of infection in mental disorders, how social evolution theory might advance new chemotherapy strategies, how viral sequences get incorporated into genomes, the role of imprinting in controlling gene expression. Participants will be in small workgroups with faculty and others who share specialized interests. Most workgroups will investigate a specific topic, for instance, malignant melanoma, cervical cancer, breast cancer, sexually transmitted diseases, antibiotic resistance, or vaccine design. Other groups will address other topics such as strategies for educating physicians, creating curriculum materials, or current debates about levels of selection. Each group will develop a possible research or teaching project, for presentation on Friday. Individuals are also free to create their own projects. Late afternoons are not prescheduled, so participants can organize their own additional discussions and projects or pursue individual interests, including recreation in Acadia National Park. Several optional preplanned expeditions are available, including whale watching, and guided hikes in the park. More information about evolutionary medicine is at The Evolution and Medicine Review
Tentative Schedule
Monday | Tuesday | Wednesday | Thursday | Friday | |
---|---|---|---|---|---|
7-8 am | Self-serve breakfast available in Dining Hall | Self-serve breakfast available in Dining Hall | Self-serve breakfast available in Dining Hall | Self-serve breakfast available in Dining Hall | Self-serve breakfast available in Dining Hall |
8-9 am | Overview of core evolutionary principles
Nesse/Faculty |
Evolution and Infectious Disease
Read |
Cancer: An introduction
Brash |
Infectious causes of cancer
Read/Maley |
Social evolution: Theory and applications to cancer progression
Aktipis |
9-10 am | Overview of core evolutionary principles
Nesse/Faculty |
Evolution and Infection in the Clinic
Read |
Cancer: Evolution
Maley |
Regulation of Defenses
Nesse |
Genetics and Personalized Medicine
Stearns |
10-10:30 am | Break | Break | Break | Break | Break |
10:30 am – 11:30 am | Life history theory and aging
Stearns |
Brainstorming on Antibiotic Resistance
Read / Woods / Schwartz |
Seminar on Methodology
Nesse / Faculty |
Teachable Moments
Schwartz |
Applications of Evolution to Cancer
Brash / Maley |
11:30-noon | Brainstorming for Workshop Topics | Discussion / Special | Discussion / Special | Discussion / Special | Discussion / Special |
Noon – 1:oopm |
Lunch | Lunch | Lunch | Lunch | Lunch |
1-2 pm | Small group discussions
Stearns: Fads and fallacies vs the evolutionary science of aging Aktipis: Hormones, behavior and reproductive cancer Nesse: The Adaptation Wars Read: Evolution-proof insecticides Schwartz: Curriculum design |
Small group discussions
Woods: Evolveability and robustness in micro-organisms Brash: Skin cancer Read: Antibiotic resistance and how to stop it Schwartz: How to do ‘Evolution Rounds’ Maley: Starting a cancer evolution program |
Small group discussions
Nesse: Organic complexity Stearns: Inferring the origins infectious diseases Maley: How to study the evolutionary biology of cancer Woods: Adaptive landscapes Aktipis: Multi-level selection |
Small group discussions
Brash: Stress responses and directed evolution Nesse: Mental disorders Schwartz: Organizing evolution-medicine interest groups Woods: Can limiting antibiotic use minimize resistance? |
Small group discussions
Aktipis: Metaphors and biases in cancer research and treatment Maley: Open questions in the evolution of cancer Stearns: the evolution of miscarriage, pre-eclampsia, and pregnancy-related diabetes Read: Vaccine driven pathogen evolution |
2:00-3:30 pm | Workgroups
Topics decided by the group Monday AM |
Workgroups | Workgroups | Workgroups | Workgroup Presentations |
3:30-5 pm | 4 pm Board bus for sunset whale watch boat trip | Open for personal activities including 4 pm volleyball | Open for personal activities including hiking (Brash) | Open for personal activities | Workgroup Presentations |
5-6 pm | Whale Watching | Dinner | Open | Dinner | Reception |
Evening | Whale Watching | Open | Dinner on your own intown |
Open | Lobster cookout |
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