Evolutionary Foundations for Medicine and Public Health: Focus on Infection and Cancer

August 6-10 at the Mount Desert Island Biological Laboratory, Bar Harbor, Maine

Registration now open.
CME credit available

This course will be limited to 40 participants.  It will be appropriate for those with a background in biology and/or medicine at diverse levels. Special expertise in evolutionary biology is not required, however those who have already studied evolutionary biology will have specialized opportunities. In order to maximize benefits to this developing field, admission preference will be offered to physicians and professors who teach or anticipate teaching courses on the subject, and to members of minority groups who may be eligible for support from the National Evolutionary Synthesis Center. Researchers and students from advanced undergraduate to postdocs will be warmly welcomed.

Faculty

Randolph Nesse – University of Michigan (Course director)
Douglas Brash — Yale University
Carlo Maley – University of California San Francisco
Athena Aktipis —  University of California San Francisco and Arizona State University
Andrew Read – Pennsylvania State University
Mark Schwartz—New York University
Stephen Stearns – Yale University
Robert Woods —  University of Michigan

Description

This intensive one-week course will introduce strategies for applying core principles of evolutionary biology to problems in medicine and public health, with a special focus on infection and cancer. The course will not attempt to cover all possible applications, it will focus on a few examples.  Some especially relevant principles include life history theory, host pathogen co-evolution, the regulation of defenses, developmental plasticity, and trade-offs shaping reproductive strategies.  These principles will be applied to clinically relevant topics including aging, antibiotic resistance, clinical management of fever, endothelial disease, prenatal experience and metabolic syndrome, and reproductive cancers. This year’s course will have extensive special expertise available on topics related to cancer and infectious disease. Mornings will be devoted to lectures and structured discussions. After lunch, participants will gather in small groups for faculty led discussions on a number of specialized topics such as strategies to prevent antibiotic resistance, the role of infection in mental disorders, how social evolution theory might advance new chemotherapy strategies, how viral sequences get incorporated into genomes, the role of imprinting in controlling gene expression. Participants will be in small workgroups with faculty and others who share specialized interests. Most workgroups will investigate a specific topic, for instance, malignant melanoma, cervical cancer, breast cancer, sexually transmitted diseases, antibiotic resistance, or vaccine design. Other groups will address other topics such as strategies for educating physicians, creating curriculum materials, or current debates about levels of selection.  Each group will develop a possible research or teaching project, for presentation on Friday. Individuals are also free to create their own projects. Late afternoons are not prescheduled, so participants can organize their own additional discussions and projects or pursue individual interests,  including recreation in Acadia National Park.  Several optional preplanned expeditions are available, including whale watching, and guided hikes in the park.  More information about evolutionary medicine is at The Evolution and Medicine Review

Tentative Schedule

 

Monday Tuesday Wednesday Thursday Friday
7-8 am Self-serve breakfast available in Dining Hall Self-serve breakfast available in Dining Hall Self-serve breakfast available in Dining Hall Self-serve breakfast available in Dining Hall Self-serve breakfast available in Dining Hall
8-9 am Overview of core evolutionary principles 

Nesse/Faculty

Evolution and Infectious Disease 

Read

Cancer: An introduction 

Brash

Infectious causes of cancer  

Read/Maley

Social evolution: Theory and applications to cancer progression 

Aktipis

9-10 am Overview of core evolutionary principles 

Nesse/Faculty

Evolution and Infection in the Clinic 

Read

Cancer: Evolution 

Maley

Regulation of Defenses 

Nesse

Genetics and Personalized Medicine 

Stearns

10-10:30 am Break Break Break Break Break
10:30 am – 11:30 am Life history theory and aging 

Stearns

Brainstorming on Antibiotic Resistance 

Read / Woods / Schwartz

Seminar on Methodology 

Nesse / Faculty

Teachable Moments 

Schwartz

Applications of Evolution to Cancer 

Brash / Maley

11:30-noon Brainstorming for Workshop Topics Discussion / Special Discussion / Special Discussion / Special Discussion / Special
Noon – 1:oopm
Lunch Lunch Lunch Lunch Lunch
1-2 pm Small group discussions 

Stearns: Fads and fallacies vs the evolutionary science of aging

Aktipis: Hormones, behavior and reproductive cancer

Nesse: The Adaptation Wars

Read: Evolution-proof insecticides

Schwartz: Curriculum design

Small group discussions 

Woods: Evolveability and robustness in micro-organisms

Brash: Skin cancer

Read: Antibiotic resistance and how to stop it

Schwartz: How to do ‘Evolution Rounds’

Maley: Starting a cancer evolution program

Small group discussions 

Nesse: Organic complexity

Stearns: Inferring the origins infectious diseases

Maley: How to study the evolutionary biology of cancer

Woods: Adaptive landscapes

Aktipis: Multi-level selection

Small group discussions 

Brash: Stress responses and directed evolution

Nesse: Mental disorders

Schwartz: Organizing evolution-medicine interest groups

Woods: Can limiting antibiotic use minimize resistance?

Small group discussions 

Aktipis: Metaphors and biases in cancer research and treatment

Maley: Open questions in the evolution of cancer

Stearns: the evolution of miscarriage, pre-eclampsia, and pregnancy-related diabetes

Read: Vaccine driven pathogen evolution

2:00-3:30 pm Workgroups 

Topics decided by the group Monday AM

Workgroups Workgroups Workgroups Workgroup Presentations
3:30-5 pm 4 pm Board bus for sunset whale watch boat trip Open for personal activities including 4 pm volleyball Open for personal activities including hiking (Brash) Open for personal activities Workgroup Presentations
5-6 pm Whale Watching Dinner Open Dinner Reception
Evening Whale Watching Open Dinner on your own intown
Open Lobster cookout



Discover more from The Evolution and Medicine Review

Subscribe to get the latest posts sent to your email.

Discover more from The Evolution and Medicine Review

Subscribe now to keep reading and get access to the full archive.

Continue reading