In previous commentaries (http://dev-evmedreview.pantheonsite.io/?p=1863; http://dev-evmedreview.pantheonsite.io/?p=837; http://dev-evmedreview.pantheonsite.io/?p=385), I have discussed the critical role of extensive B-cell and immunoglobulin gene evolution in...
Carcinomas of the prostate are the most common cancers affecting men and a leading cause of male cancer deaths in the United States (CDC web site, Cancer Prevention and Control). Given the unique association of the prostate with males, it makes sense that prosate...
Altshuler and colleagues (Nature Genetics, 2014) recently reported a study of about 150,000 individuals representing five different ancestral groups in which they identified twelve low-frequency variants of the gene SLC30A8 through either genomic sequencing or...
In a previous post (http://evomed.org/?p=1034), I discussed a study from Stuart Orkin’s lab that illustrated the exploitation of genetic variants that influence a disease-related phenotype to design a possible therapy for a murine version of sickle cell disease. ...
Christiane Goulart and Miriam Barlow and colleagues have published an important study in this month’s PLOS One entitled “Designing Antibiotic Cycling Strategies by Determining and Understanding Local Adaptive Landscapes.” Because of the growing...