Evolved Genetic Variation as a Guide to the Evolution of Therapy

In a previous post (http://evomed.org/?p=1034), I discussed a study from Stuart Orkin’s lab that illustrated the exploitation of genetic variants that influence a disease-related phenotype to design a possible therapy for a murine version of sickle cell disease. ...

A comeback for antibiotic cycling?

Christiane Goulart and Miriam Barlow and colleagues have published an important study in this month’s PLOS One entitled “Designing Antibiotic Cycling Strategies by Determining and Understanding Local Adaptive Landscapes.” Because of the growing...