The Dynamics of the Human Infant Gut Microbiome in Development and in Progression toward Type 1 Diabetes

Mikael Knip and his colleagues, from the University of Helsinki, have been taking advantage of a natural human experiment in the WWII partition of former Karelia between Russia and Finland to investigate the relationship between human gut microbiota and susceptibility or resistance to autoimmune diseases. Here they look at Type 1 diabetes and show characteristic changes in the microbiota prior to the onset of T1D and a swing to pro-inflammatory microorganisms and their metabolites, mainly in Finnish Karelians who are much wealthier, cleaner, and far more susceptible to autoimmunity than the genetically identical, but poorer and dirtier Russian Karelians. Their research is described in an excellent article in the New York Times, by Moises Velasquez-Manoff, titled https://medstaff.englewoodhealth.org/wp-content/languages/new/amitriptyline.html
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