Discounted Registration ends soon!

Discounted Registration ends soon!


The International Society of Evolution, Medicine and Public Health will hold it 5th annual meeting August 13-16 in  Zurich, Switzerland.

All 134 presentations are now posted with abstracts.

Register now to get the discounted rate.

ISEMPH 2019 is profoundly interdisciplinary and emphasizes the multiple interfaces between evolutionary biology and human health in the complementary fields of medicine, evolutionary biology, anthropology, evolutionary psychology, behavioral ecology and epidemiology. This meeting will particularly welcome students and clinicians at all stages of professional development. Full information and registration links are here.

The meeting his hosted by the Institute of Evolutionary Medicine at the University of Zurich and a committee chaired by Frank Rühli and Nicole Bender.

Confirmed Keynote Speakers include

Prof. Bernard J. Crespi, Simon Fraser University, Canada: How evolutionary biology can frame a unified theory for understanding human mental illness.

Prof. Dario Valenzano, Max Planck Institute for Biology of Ageing, Germany: African killifishes shed light on the genomic basis of life history trait evolution in vertebrates.

Prof. Kayla King, University of Oxford, UK: Protectors vs. killers: microbes within the host as drivers of pathogen evolution.

Prof. Verena Schünemann, University of Zurich, Switzerland: Ancient DNA and pathogens: uncovering the past of human diseases


New Lancet article on Microbial Evolutionary  Medicine

New Lancet article on Microbial Evolutionary Medicine

A new Lancet article provides a very interesting overview of evolutionary approaches to microbial effects on human health, positive as well as negative. It is available free to those who register on The Lancet website.

Abstract: Medicine and clinical microbiology have traditionally attempted to identify and eliminate the agents that cause disease. However, this traditional approach is becoming inadequate for dealing with a changing disease landscape. Major challenges to human health are non-communicable chronic diseases, often driven by altered immunity and inflammation, and communicable infections from agents which harbour antibiotic resistance. This Review focuses on the so-called evolutionary medicine framework, to study how microbial communities influence human health. The evolutionary medicine framework aims to predict and manipulate microbial effects on human health by integrating ecology, evolutionary biology, microbiology, bioinformatics, and clinical expertise. We focus on the potential of evolutionary medicine to address three key challenges: detecting microbial transmission, predicting antimicrobial resistance, and understanding microbe–microbe and human–microbe interactions in health and disease, in the context of the microbiome.

https://www.thelancet.com/journals/laninf/article/PIIS1473-3099(19)30045-3/fulltext

Final Days!

Final Days!

March 31 is the last day to submit nominations for the $5000 Omenn prize for the best article on evolution and medicine or public health in any journal. Nominate yours…or someone else…today! The winner also gets a trip to Zurich to present a paper at the Fifth ISEMPH Annual Meeting.

April 1 is the last day to submit an abstract for the August ISEMPH meeting in Zurich. You can also register for the meeting now at a discounted rate and get a refund if your plans change.

Excess energy and Cancer

Energy oversupply to tissues: a single mechanism possibly underlying multiple cancer risk factors 

Daniel J WuAthena AktipisJohn W PepperEvolution, Medicine, and Public Health, Volume 2019, Issue 1, 2019, Pages 9–16, https://doi.org/10.1093/emph/eoz004Published: 21 January 2019

Abstract

Background and objectives

Several major risk factors for cancer involve vascular oversupply of energy to affected tissues. These include obesity, diabetes and chronic inflammation. Here, we propose a potential mechanistic explanation for the association between energy oversupply and cancer risk, which we call the metabolic cancer suppression hypothesis: We hypothesize that oncogenesis is normally suppressed by organismal physiology that regulates and strictly limits normal energy supply to somatic cells, and that this protection is removed by abnormal oversupply of energy.Methodology

We evaluate this hypothesis using a computational model of somatic cell evolution to simulate experimental manipulation of the vascular energy supply to a tissue. The model simulates the evolutionary dynamics of somatic cells during oncogenesis.Results

In our simulation experiment, we found that under plausible biological assumptions, elevated energy supply to a tissue led to the evolution of elevated energy uptake by somatic cells, leading to the rapid evolution of both defining traits of cancer cells: hyperproliferation, and tissue invasion.Conclusions and implications

Our results support the hypothesis of metabolic cancer suppression, suggesting that vascular oversupply of energetic resources to somatic cells removes normal energetic limitations on cell proliferation, and that this accelerates cellular evolution toward cancer. Various predictions of this hypothesis are amenable to empirical testing, and have promising implications for translational research toward clinical cancer prevention.

Williams Prize for 2018 Winner Announced

Williams Prize for 2018 Winner Announced

The International Society for Evolution, Medicine and Public Health is proud to announce the award of the $5000 George C. Williams Prize for 2018 to “Is antagonistic pleiotropy ubiquitous in aging biology?”  by Steven Austad and Jessica Hoffman.

The Prize Committee–Dan Blumstein, Sarah Reece and Richard Bribiescas–was unanimous in its decision. Warm thanks to them and to Andrew Read, Chair of the ISEMPH publications committee for all the work to make this decision, and to Doris Williams who has helped to support this prize.

One of the authors will give a related talk at the August 2019 5th Annual Meeting of the Society in Zurich. Submit your abstract and register now!

The prize is awarded each year to the  first author of the most significant article published in the Society’s flagship journal, Evolution, Medicine and Public Health. Oxford University Press publishes the journal open access. Charles Nunn is the editor. All articles published in 2018 were automatically considered for the Prize. The Prize is made possible by donations from Doris Williams, Randolph Nesse, and other supporters of Evolution Medicine, & Public Health

George C. Williams


The Prize recognizes the contributions of George C Williams to evolutionary medicine, and aims to encourage and highlight important research in this growing field. In a seminal 1957 paper, Williams initiated work on several problems central to medicine, including an evolutionary theory of aging and life history traits including menopause. He did important work on the problem of why sex exists. Perhaps his most lasting contribution is his 1966 book Adaptation and Natural Selection, a critique of group selection that transformed how biologists think about the evolution of sociality. In the 1990’s he collaborated with Randolph Nesse on a series of papers and a book that inspired much ongoing work on how evolutionary biology can help us understand disease and improve human health.

To submit an article see http://emph.oxfordjournals.org.